Effects of Subthalamic Deep Brain Stimulation on Blink Abnormalities of 6-OHDA Lesioned
نویسندگان
چکیده
9 1 Program of Integrative Neuroscience. Dept. Psychology, Stony Brook University, Stony 10 Brook, NY 11794-5230, 2 Program in Neuroscience, Stony Brook University, Stony Brook, NY 11 3 Dept. Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794-5230, 12 4 SUNY Eye Institute, Syracuse, NY, USA, 5 current address Center for Molecular and Behavioral 13 Neuroscience, Rutgers University, Newark, NJ 07102-1811 14
منابع مشابه
CALL FOR PAPERS Neurobiology of Deep Brain Stimulation Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats
Kaminer J, Thakur P, Evinger C. Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA-lesioned rats. J Neurophysiol 113: 3038–3046, 2015. First published February 11, 2015; doi:10.1152/jn.01072.2014.—Parkinson’s disease (PD) patients and the 6-hydroxydopamine (6-OHDA) lesioned rat model share blink abnormalities. In view of the evolutionarily conserved organization of b...
متن کاملEffects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats.
Parkinson's disease (PD) patients and the 6-hydroxydopamine (6-OHDA) lesioned rat model share blink abnormalities. In view of the evolutionarily conserved organization of blinking, characterization of blink reflex circuits in rodents may elucidate the neural mechanisms of PD reflex abnormalities. We examine the extent of this shared pattern of blink abnormalities by measuring blink reflex excit...
متن کاملStriatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
OBJECTIVE High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson's disease. However, the neurochemical basis of its effects remains unknown. The aim of this study is to investigate the effects of STN HFS in intact and 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rat model on changes of principal neurotransmitters, ...
متن کاملHigh frequency stimulation of the subthalamic nucleus improves treadmill locomotion in unilateral 6-hydroxydopamine lesioned rats.
This study investigated the influence of electrical stimulation of the subthalamic nucleus (STN) on motor impairment induced by unilateral 6-hydroxydopamine (6-OHDA) lesions in the medial forebrain bundle. Rats were trained to walk on a treadmill and then implanted with microelectrode arrays in and near the STN. The neurotoxin 6-OHDA was injected into the medial forebrain bundle (MFB) unilatera...
متن کاملThe electrocorticogram signal can be modulated with deep brain stimulation of the subthalamic nucleus in the hemiparkinsonian rat.
Electrocorticogram (ECoG) recordings of the 6-hydroxydopamine (6-OHDA)-lesioned parkinsonian rat have shown an increase in the power of cortical beta-band (15-30 Hz) oscillations ipsilateral to the lesion. The power of these oscillations is decreased with dopamine agonist administration. Here, we demonstrate that stimulation of an electrode implanted in the subthalamic nucleus alters the power ...
متن کامل